Page 1266 - Veterinary Immunology, 10th Edition

with caution. Administration of propylthiouracil to cats with
VetBooks.ir hyperthyroidism may result in the development of a syndrome

resembling lupus. This may include the development of an
antiglobulin-positive anemia as well as positive ANA reactions.

FIG. 38.7 Three positive ANA reactions. These are indirect
fluorescent antibody reactions in which dog serum under test is
layered onto a cell culture. After washing, the bound antibody is
detected using a fluorescent antiglobulin. Although “rim”
fluorescence (A) has traditionally been considered a positive
reaction, the staining pattern obtained appears to depend in large

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