Page 1262 - Veterinary Immunology, 10th Edition

Lupus affects middle-aged dogs (between 2 and 12 years of age)
VetBooks.ir and affects males more than females. The disease is commonly seen

in Collies, German Shepherds, Nova Scotia Duck Tolling Retrievers,
and Shetland Sheepdogs, but Beagles, Irish Setters, Poodles, and

Afghan Hounds are also affected. Lupus (or positive lupus
serology) may occur in related animals, supporting the importance
of genetic factors. For example, dogs possessing the MHC class I
antigen DLA-A7 are at increased risk and those possessing DLA-A1

and -B5 are at decreased risk for developing disease (Fig. 38.6).
When dogs with lupus are bred, the number of affected offspring is
higher than can be accounted for genetically, suggesting that the
disease may be vertically transmitted. A type C retrovirus has been

suggested as a potential trigger of lupus.

FIG. 38.6 The inheritance of canine systemic lupus
erythematosus. This diagram shows four generations of a single
family of dogs. Colored squares (male) or circles (female) denote
those animals exhibiting clinical signs of systemic lupus; “+” denotes
animals positive for antinuclear antibodies. (From Teichner M,
Krumbacher K, Doxiadis I, et al: Systemic lupus erythematosus in dogs: association
to the major histocompatibility complex class I antigen DLA-A7, Clin Immunol

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