Page 1300 - Veterinary Immunology, 10th Edition
P. 1300
VetBooks.ir Inherited Defects in the Adaptive
Immune System
Inherited immunological defects have served to confirm the overall
arrangement of the immune system, as outlined in Fig. 39.5. For
example, if both the cell- and antibody-mediated immune responses
are defective, it may be assumed that the genetic lesion operates at a
point prior to thymic and bursal cell processing. That is, a stem cell
lesion. A defect that occurs only in thymic development leads to a
failure to mount cell-mediated immune responses, although
antibody production may be normal. Similarly, a lesion restricted to
B cells is reflected by impaired antibody responses.
FIG. 39.5 The points in the immune system where development
blocks may lead to immunodeficiencies.
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