Page 1376 - Veterinary Immunology, 10th Edition
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FIG. 41.2 The structure of some commonly employed
immunosuppressive drugs and the normal compounds with which
they compete. Cyclophosphamide acts by cross-linking DNA
chains.
Folic Acid Antagonists
Methotrexate is a folic acid antagonist that binds to dihydrofolate
reductase and blocks the synthesis of tetrahydrofolate, inhibiting
the synthesis of thymidine and purine nucleotides. As a result, it
can suppress antibody formation. Its side effects are similar to those
caused by cyclophosphamide. It is used for the treatment of
rheumatoid arthritis in humans.
DNA Synthesis Inhibitors
Azathioprine is a nucleoside analog that suppresses lymphocyte
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