Page 1356 - Problem-Based Feline Medicine

1348 PART 16 DRUGS

In a recent study of affected cats, the daily and total and progesterone. Adverse effects appear to be mini-
doses of enrofloxacin administered and the duration of mal, and limited to dry hair coat and weight loss.
treatment were highly variable.
Recommended dose
Recommended dose 5–10 mg/kg q 8–12 h PO.
5 mg/kg sid.

FUROSEMIDE LIGNOCAINE

Clinical action Clinical action
Diuretic. Anti-arrhythmic.
Adverse effects Adverse effects
Cats appear to be more sensitive to the effects of Toxicosis results in myocardial depression and CNS
furosemide than dogs. signs including drowsiness, depression, ataxia and
muscle tremors, and occurs more commonly in cats.
Dose
1–2 mg/kg bid.
Dose
0.25–0.75 mg/kg IV slowly.
GRISPEOFULVIN

Clinical action
MEGESTROL ACETATE
Anti-fungal.
Clinical action
Adverse effects
Synthetic progestagen used for reproductive, behav-
Bone marrow hypoplasia manifested as leukopenia
ioral and dermatologic disorders.
and thrombocytopenia. This is believed to be an idio-
syncratic reaction. Cats with FIV infection appear to be
at an increased risk. Adverse effects
The most serious side effects associated with megestrol
Non-reversible ataxia has also been reported in a kitten
acetate include mammary hypertrophy and neoplasia,
treated with the drug.
cystic endometritis and diabetes mellitus.
Recommended dose The mechanism for diabetes mellitus appears to be dif-
ferent than in the dog (where it relates to increased
50 mg/kg/day PO (may be given in divided doses and
growth hormone production).
should be administered with a fatty meal to enhance
absorption). Megestrol-induced diabetes in the cat may be transient
or permanent. Megestrol acetate also causes adrenal
KETOCONAZOLE suppression in the cat.
Clinical action Recommended dose
Anti-fungal. Megestrol acetate is not recommended for the treat-
ment of behavioral or dermatologic disorders due to the
Adverse effects risk of serious side effects.
In contrast to dogs, ketoconazole does not alter produc- Control of estrus can be achieved by using 5 mg/cat for
tion of steroid hormones such as cortisol, testosterone 3 days then 2.5–5 mg once/week for 10 weeks.