Page 1358 - Problem-Based Feline Medicine

1350 PART 16 DRUGS

Adverse effects species due to their unique protein metabolism and
There appears to be a greater prevalence of adverse requirements.
effects in cats compared to dogs (50%) in one study.
THIACETARSAMIDE
Coughing of sufficient severity to lead to euthanasia or
discontinuation of medication has been reported.
Clinical action
Adulticide (dirofilariasis).
Dose
30 mg/kg/day. Adverse effects
Cats appear to be relatively susceptible to the acute
TETRACYCLINES toxic effects of thiacetarsamide.
Drug fever and respiratory distress may develop.
Clinical action
Antibiotic. In one study 25% of cats treated died from fulminant
pulmonary edema.
Adverse effects
Hepatic lipidosis, increased ALT activity, ptyalism and Recommended dose
anorexia have been reported in a cat treated with tetra- 2.2 mg/kg q 12 h for 2 days.
cycline.
It has been speculated that cats may be more suscepti-
ble to tetracycline-induced hepatotoxicosis than other

RECOMMENDED READING

Boothe DM. Drug therapy in cats: mechanisms and avoidance of adverse drug reactions. J Am Vet Med Assoc 1990;
196: 1297–1305.
Boothe DM. Drug therapy in cats: a systems approach. J Am Vet Med Assoc 1990; 196: 1502–1511.
Boothe DM. Drug therapy in cats: a therapeutic category approach. J Am Vet Med Assoc 1990; 196: 1659–1669.
Boothe DM. Drug therapy in cats: recommended dosing regimens. J Am Vet Med Assoc 1990; 196: 1845–1850.
Boothe DM, George KL, Couch P. Disposition and clinical use of bromide in cats. J Am Vet Med Assoc 2002; 221:
1131–1135.
Plumb DC. Veterinary Drug Handbook, 3rd edn. Iowa State University Press, 1999.