Page 1060 - The Toxicology of Fishes

1040 The Toxicology of Fishes

lymphomas, 558 Mauthner cells, 422, 424, 427, 428, 430, 434, 436,
lymphoproliferation, 512 439, 445, 814
lysine, 194, 294 maximum acceptable toxicant concentration
lysine hydroxylase, 283 (MATC), 677, 758
lysosomes, 278, 292, 336, 372–373, 377, 409, 477 mayflies, 793, 794
alterations in, 378 Mdr1, 354, 361, 362, 378; see also P-glycoprotein
morphological changes in, 711 (Pgp)
lysozymes, 490, 494 Mdr3, 361, 362
mean lethal concentration, see LC 50
M mean residence time, 124–125
macrobenthic community, 737 mean time to death (TTD), 799
macrofauna, 792 measurement endpoints, 745, 762
α -macroglobulin, 494 mechanisms of action, 4, 5, 684, 685
2
macroinvertebrates, 737, 741, 742, 743 AhR-mediated, 39
macrophage aggregates (MAs), 374, 377, 492, carcinogens, 539, 542, 549
495, 511 determining, 669, 709
pigmented, 342, 495, 930 in kidney, 409
macrophage-activating factor (MAF), 495 molecular, 426
macrophages (MØs), 276, 278, 335, 374, 490, mutants, 574
491, 492, 493, 495, 496, 500, 502, 503, 508, neurobiotics, 428
510, 512 neurotoxic, 418, 425, 440
hepatotoxicants, and, 368 organic chemicals, 427
interhepatocytic, perisunsoidal, 341–342 organochlorine insecticides, 437
splenic, 342 procarcinogens, 213
macrophytes, 741, 742–743 pyrethroids, 435
macrozooplankton, 740 secondary, synthetic pyrethroids, 812,
macula, 424 813–814
magnesium, 13, 30, 279, 406, 440 xenobiotics, 566
-dependent ATPase, 338 medaka (Oryzias latipes), 76, 113, 119, 169, 172,
mahogany snapper (Lutjanus mahogoni), 173, 174, 177, 214, 237, 339, 343, 351, 353,
ciguatera toxins, and, 444 436, 513, 571, 577, 578
Maine, 181 2-acetylaminofluorene, and, 369
major histocompatibility complex (MHC), 496, AChE inhibition in, 178
624, 899 aldicarb, and, 214
malathion, 434, 504, 504–505 anal aperture, 347
malaxon, 504 BaP, and, 511
male ovipositor formation, 951 bile acids in, 355
maleic hydrazide, 300 BSEP-like protein in, 363
malondialdehyde, 544 cadmium, and, 500
mammillary configuration, 96–97 carbaryl, and, 434
manganese, 37 chemical carcinogenesis in, 565–566
manganese superoxide dismutase (MnSOD), chloroform, and, 371
278–279, 286, 288, 308 chlorpyrifos, and, 434
Marley sewage treatment works, 975, 976, 984, CYP1A, 162
985, 989, 994 CYP3A38, 172
mas, 557 CYP3A38/CYP3A40, recombinant, 172
masculinization, 470, 951 embryos, 44
mass balance models, 646–657, 760 endosulfan, and, 439
massively parallel signature sequencing (MPSS), estradiol, and, 177
252 17β-estradiol, and, 173, 987
maternal transfer, of xenobiotics, 91, 123 fat-storing cells in, 341
maturation-inducing steroids (MISs), 461 hepatic neoplasia in, 537
maturation-promoting factor (MPF), 461 hepatocarcinogenesis in, 367, 564