Page 1904 - Saunders Comprehensive Review For NCLEX-RN

7. Assure the client that hirsutism is reversible; instruct
on depilatory (hair removal) methods.
8. Other adverse effects include neurotoxicity,
gastrointestinal effects, hyperkalemia, and
hyperglycemia.
9. The risk of infection and lymphomas is increased with
the use of cyclosporine.
10. Cyclosporine is contraindicated in the presence of
hypersensitivity, pregnancy and breast-feeding,
recent inoculation with live virus vaccines, and recent
contact with an active infection such as chickenpox or
herpes zoster.
11. Cyclosporine is embryotoxic, and women of
childbearing age should use a mechanical form of
contraception and avoid oral contraceptives.
12. The client should be informed about the possibility of
renal damage and liver damage and the need for
periodic liver function tests and determination of
coagulation factors and blood urea nitrogen, serum
creatinine, serum potassium, and blood glucose
levels.

13. The client should be instructed to monitor for

early signs of infection and to report these signs
immediately.

14. Available in a pill form; if the client is unable

to swallow the pill, instruct the client to follow the
medication administration instructions exactly;
dispense the oral liquid medication into a glass
container using a specially calibrated pipette, mix
well, and drink immediately; rinse the glass container
with diluent and drink it to ensure ingestion of the
complete dose; dry the outside of the pipette and
return to its cover for storage.
15. To promote palatability, instruct the client to mix the
liquid medication with milk, chocolate milk, or
orange juice just before administration.

16. Consuming grapefruit juice is prohibited

because it raises cyclosporine levels and increases the
risk of toxicity.
17. Ketoconazole, erythromycin, and amphotericin B can
elevate cyclosporine levels.
18. Phenytoin, phenobarbital, rifampin, and trimethoprim-
sulfamethoxazole can decrease cyclosporine levels.
19. Renal damage can be intensified by the concurrent use

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