Page 49 - Children Bookt.pdf

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children before adolescence.

(b) EFV is not currently recommended for children <3 years of age, and should
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such as fever, oral lesions, blistering, facial oedema, conjunctivitis; Stevens
– Johnson syndrome can be life-threatening. For life-threatening rash, most
clinicians would not substitute EFV because of the potential for NNRTIclass

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limitations in the choice of drugs in the event of treatment failure.

(e) Lactic acidosis is least commonly associated with ABC, therefore ABC should
replace AZT or d4T whenever lactic acidosis occurs.
(f) In children, ABC or AZT can be considered as an alternative.

(g) Substitution of d4T often may not reverse lipoatrophy.

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as Hb <7.5 g/dl.
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ingestion of ARV drug regimen (e.g. persistent nausea and vomiting)

(k) E.g. persistent hallucinations or psychosis
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infants.

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