Page 48 - Children Bookt.pdf

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clinicians would avoid substituting another NNRTI drug (EFV) because of the potential
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(i.e. substituting ABC, for NVP), or substituting a PI for NVP, thereby introducing a
drug class usually reserved for second-line regimens.

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drug substitutions
Responsible ## &>#
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ARV substitution
b
Acute symptomatic hepatitis a NVP EFV
Hypersensitivity reaction /

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Severe or life-threatening rash be less potent) or
(Stevens – Johnson syndrome) c –/!@$
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start of class usually reserved for
second-line)
d
Lactic acidosis d4T ABC e
Peripheral neuropathy AZT or ABC f
Pancreatitis
Lipoatrophy/metabolic syndrome g ABC
h
Severe anaemia or neutropaenia i AZT d4T or ABC
Lactic acidosis ABC e
Severe gastrointestinal intolerance 8 d4T or ABC
Persistent and severe central
EFV NVP
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Potential teratogenicity
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of pregnancy, or of childbearing
potential and not receiving
adequate contraception)
Hypersensitivity reaction ABC AZT
Lipoatrophy/metabolic syndrome LPV/r l NNRTI
Dyslipidaemia
Severe diarrhoea

Note: 3TC/FTC-associated pancreatitis has been described in adults but is considered
very rare in children.

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