Page 1071 - Basic _ Clinical Pharmacology ( PDFDrive )

CHAPTER 59 Special Aspects of Perinatal & Pediatric Pharmacology 1057

TABLE 59–6 Determination of drug dosage from Hansten PD, Horn JR: Drug Interactions, Analysis and Management. Facts &
surface area. 1 Comparisons. [Quarterly.]
International Liaison Committee on Resuscitation: The International Liaison
Committee on Resuscitation (ILCOR) consensus on science with treatment
Weight recommendations for pediatric and neonatal patients: pediatric basic and
Approximate Surface Percent of advanced life support. Pediatrics 2006;117:e955.
2
(kg) (lb) Age Area (m ) Adult Dose
Iqbal MM, Sohhan T, Mahmud SZ: The effects of lithium, valproic acid, and
3 6.6 Newborn 0.2 12 carbamazepine during pregnancy and lactation. J Toxicol Clin Toxicol
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6 13.2 3 months 0.3 18 Ito S: Drug therapy for breast feeding women. N Engl J Med 2000;343:118.
10 22 1 year 0.45 28 Kearns GL et al: Developmental pharmacology—drug disposition, action and
20 44 5.5 years 0.8 48 therapy in infants and children. N Engl J Med 2003;349:1157.
Koren G: Medication Safety during Pregnancy and Breastfeeding; A Clinician’s Guide,
30 66 9 years 1 60 4th ed. McGraw-Hill, 2006.
40 88 12 years 1.3 78 Koren G, Nordeng H: Antidepressant use during pregnancy: The benefit-risk ratio.
Am J Obstet Gynecol 2012;207:157.
50 110 14 years 1.5 90
Koren G, Pastuszak A: Prevention of unnecessary pregnancy terminations by
60 132 Adult 1.7 102 counseling women on drug, chemical, and radiation exposure during the
first trimester. Teratology 1990;41:657.
70 154 Adult 1.76 103
Koren G, Pastuszak A, Ito E: Drugs in pregnancy. N Engl J Med 1998;
1 For example, if adult dose is 1 mg/kg, dose for 3-month-old infant would be 0.18 mg/kg 338:1128.
or 1.1 mg total. Koren G et al: Sex differences in the pharmacokinetics and bioequivalence of the
Reproduced, with permission, from Silver HK, Kempe CH, Bruyn HB: Handbook of delayed-release combination of doxylamine succinate-pyridoxine hydro-
Pediatrics, 14th ed. Originally published by Lange Medical Publications. © 1983 by the chloride: Implications for pharmacotherapy in pregnancy. J Clin Pharmacol
McGraw-Hill Companies, Inc. 2013;53:1268.
Madadi P et al: Pharmacogenetics of neonatal opioid toxicity following maternal
use of codeine during breastfeeding: A case control study. Clin Pharmacol
Despite these approximations, only by conducting studies in Ther 2009;85:31.
children can safe and effective doses for a given age group and Namouz-Haddad S, Koren G: Fetal pharmacotherapy 2: Fetal arrhythmia.
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Pauwels S, Allegaert K: Therapeutic drug monitoring in neonates. Arch Dis Child
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