Page 545 - Basic _ Clinical Pharmacology ( PDFDrive )

CHAPTER 29 Antipsychotic Agents & Lithium 531

C ASE STUD Y ANSWER

Schizophrenia is characterized by a disintegration of more effective for treating negative symptoms and cogni-
thought processes and emotional responsiveness. Symp- tive dysfunction and have lower risk of tardive dyskinesia
toms commonly include auditory hallucinations, paranoid and hyperprolactinemia. Other indications for the use of
or bizarre delusions, disorganized thinking and speech, and selected antipsychotics include bipolar disorder, psychotic
social and occupational dysfunction. For many patients, depression, Tourette syndrome, disturbed behavior in
first-generation (eg, haloperidol) and second-generation patients with Alzheimer’s disease and in the case of older
agents (eg, risperidone) are of equal efficacy for treating drugs (eg, chlorpromazine), treatment of emesis, and
positive symptoms. Second generation agents are often pruritus.