Page 804 - Basic _ Clinical Pharmacology ( PDFDrive )

790 SECTION VII Endocrine Drugs

Mechanism of Clinical
Subclass, Drug Action Effects Applications Toxicities
HORMONES
• Teriparatide These hormones act via their Teriparatide stimulates bone turnover Both are used in Teriparatide may cause
• Abaloparatide cognate G protein–coupled • calcitonin suppresses bone osteoporosis • calcitonin hypercalcemia and
• Calcitonin receptors resorption is used for hypercalcemia hypercalciuria
• rhPTH1-84 Recombinant full-length rhPTH1-84 increases RANKL, Hypoparathyroidism Hypercalcemia, hypercalciuria
PTH; acts on the same decreases sclerostin, enhances
receptors as teriparatide calcium reabsorption from the kidney
SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMs)
• Raloxifene Interacts selectively with Inhibits bone resorption without Osteoporosis Does not prevent hot flashes
estrogen receptors stimulating breast or endometrial • increased risk of venous
hyperplasia thromboembolism
RANK LIGAND (RANKL) INHIBITOR
• Denosumab Monoclonal antibody • binds Blocks bone resorption Osteoporosis May increase risk of infections
to RANKL and prevents it
from stimulating osteoclast
differentiation and function
CALCIUM RECEPTOR AGONIST
• Cinacalcet Activates the calcium- Inhibits PTH secretion Hyperparathyroidism Nausea
sensing receptor
MINERALS
• Calcium, Multiple physiologic actions Strontium suppresses bone Osteoporosis Ectopic calcification
phosphate through regulation of resorption and increases bone • osteomalacia
• Strontium multiple enzymatic formation • calcium and phosphate • deficiencies in calcium
pathways required for bone mineralization or phosphate

PREP AR A TIONS A V AIL ABLE

GENERIC NAME AVAILABLE AS GENERIC NAME AVAILABLE AS
VITAMIN D, METABOLITES, AND ANALOGS PHOSPHATE AND PHOSPHATE BINDER
Calcifediol (25(OH)D3) Rayaldee Phosphate
Calcitriol Oral: solution Fleet Phospho-soda, K-Phos-
Oral Generic, Rocaltrol Neutral, Neutra-Phos, Neutra-
Phos-K
Parenteral Calcijex
Sevelamer carbonate or HCl Renagel, Renvela
Cholecalciferol (D 3 ) Generic, Delta-D
(vitamin D 3 ) Lanthanum carbonate Fosrenol
Doxercalciferol Generic, Hectorol BISPHOSPHONATES
Ergocalciferol (D 2 ) (vitamin Generic, Drisdol, others Alendronate sodium Generic, Fosamax
D 2 , calciferol) Etidronate disodium Generic, Didronel
Paricalcitol Generic, Zemplar Ibandronate sodium Generic, Boniva
CALCIUM Pamidronate disodium Generic, Aredia
Calcium acetate (25% calcium) Generic, PhosLo Risedronate sodium Actonel, Atelvia
Calcium carbonate (40% calcium) Generic, Tums, Cal-Sup, Os-Cal 500 Tiludronate disodium Skelid
Calcium chloride (27% calcium) Generic Zoledronic acid Zometa
Calcium citrate (21% calcium) Generic, Cal-C-Caps, Cal-Cee OTHER DRUGS
Calcium glubionate Neo-Calglucon, Calcionate, Calcitonin-salmon Miacalcin, Calcimar, Salmonine
(6.5% calcium) Calciquid Cinacalcet Sensipar
Calcium gluceptate Generic Denosumab Prolia, Xgeva
(8% calcium) Gallium nitrate Ganite
Calcium gluconate Generic
(9% calcium) Sodium fluoride Generic
Calcium lactate (13% calcium) Generic Teriparatide (1-34 active segment Forteo
of PTH)
Tricalcium phosphate Posture
(39% calcium) Recombinant human PTH 1-84 Natpara