Page 104 - Book of Abstracts 2020
P. 104
th
8 Biannual Conference on Chemistry - CHEM 08
Ferrous Complexes of Two Antibiotic Drugs: Spectroscopic,
Molecular docking, DNA binding and Thermogravimetric
studies
Abeer A. sharfalddin , Mostafa A. Hussien .
1,2
1
1 Department of Chemistry, Faculty of Science, King Abdulaziz
University, P.O. Box 80203 Jeddah 21589, Saudi Arabia, Department of
2
Chemistry, Faculty of Science, Port Said University, Port Said, 42521,
Egypt
Email: sharfalddin.aa@hotmail.com
ABSTRACT
New ferrous complexes of antibiotic drug compounds (Sulfaclozine and
Thiamphenicol) were synthesized with Fe:Ln molar ratio of 1:2. The
complexes were characterized by elemental analyses, IR, UV–vis. spectra,
magnetic and thermal instruments. The results of the molar conductance
measurements reveal that all the complexes have no electrolytic behavior.
The infrared spectra show that both drug ligands act as a bidentate
chelate, Sulfaclozine coordinates through sulfonyl oxygen atoms
and pyrazine nitrogen, while the Thiamphenicol ligand bind toward Fe
(II) ion via both hydroxyl oxygen atom. The spectroscopic results suggest
octahedral geometry for all Fe (II) complexes. The kinetic thermodynamic
parameters of the essential DTGmax decomposition steps were calculated.
The evaluation of cytotoxicity of Fe (II) complexes against HCT-116 and
MCF-7 cell line were performed. Moreover, the antimicrobial activities
(bacteria) of the complexes were assessed in comparison with the ligand.
BOOK OF ABSTRACTS CHEM 08 (2020) Page 103
