Page 21 - Book of Invited & Keynotes Talks

th
8 Biannual Conference on Chemistry - CHEM 08

Photodynamic Modality for Cancer Diagnosis & Therapy and
for Control of Malaria Vector in Infested African Swamps
Mahmoud H. Abdel-Kader

Cairo University Founder and Chairman of the European University in
Egypt, EUE

ABSTRACT

Photodynamic Therapy (PDT) is a promising new modality for cancer diagnosis
and treatment, which involves the combination of light of an appropriate wavelength
and a photosensitizing agent, which is selectively taken up and retained by tumor
cells. Separately, each of these factors is harmless; however when they are combined
in the presence of oxygen, cytotoxic reactive oxygen species are produced, which
leads to irreversible cellular damage and causes cell death and tumor destruction.
The following advantages of PDT makes it a very promising modality for cancer
diagnosis and therapy e.g. selective destruction of cancer tissues, sensitizers located
within the cytoplasm (no DNA damages), reduction of the metastatic rate of treated
tissues, few drug-to-drug interactions and no impairment of further adjuvant
treatments, as well as from the technical point of view e .g efficacy, easy to handle
and low cost. This work will introduce the different applications of PDT as well as
the methods and techniques of applying it on several types of cancer diagnosis and
therapy.
In addition, the successful field implementation of using Photodynamic modality
utilizing natural extracts of chlorophyll derivatives and sunlight to control Malaria,
Schistosomiasis and agricultural pests will be presented. In conclusion, this
workintroduces a novel method, with low cost, that combines effectiveness, high
selectivity, and highest levels of human safety and environmental friendliness.

BOOK OF INVITED SPEAKERS & KEYNOTES CHEM 08 (2020) Page 21