Page 73 - Book of Invited & Keynotes Talks

th
8 Biannual Conference on Chemistry - CHEM 08

Protein Affinity of Photo Stable and Photoactivatable Metal-
Based Compounds
Ahmed Mansour
Chemistry Department-Faculty of Science-Cairo University, Giza, Egypt.

ABSTRACT
Metal based compounds have unique physicochemical properties that can be efficiently
used in medicinal chemistry. Both mass spectrometry measurements and X-ray
crystallographic analysis presented conversant and reasonable evidences that
organometallic and coordination compounds can act via the interaction with DNA
and/or enzymes. Recently, CO showed interesting biological effects (anti-
1
inflammatory, anti-proliferative and signaling properties), in the concentration range of
10–250 ppm, which encouraged researchers to explore the ways by which CO can be
2
selectively and specifically administrated into the body without delivering whole
toxicity. Carbon monoxide releasing molecules (CORMs) were introduced as an alternative
way to the inhalation system. Photoactivatable metal carbonyl compounds received
much interest as CO prodrug capable of carry and deliver CO upon the exposure to a
certain wavelength. Following the administration of CORMs, there is a highly
probability to bind to surface-accessible histidyl of proteins. The questions of stability
of CORMs in presence of biomolecules and the probability of bioconjugation to carry
CORMs into their specific targets are still of significant general interest to bioinorganic
chemists as well as other researchers interested in the chemistry of small signaling
molecule such as CO.
Keyword: Carbon monoxide releasing molecules; Protein affinity; Photoactivatable; X-
ray Crystallography

1 A. Nakao, D. J. Kaczorowski, R. Sugimoto, T. R. Billiar, and K. R. McCurry, J. Clin. Biochem. Nutr.,
2008, 42, 78; H. P. Kim, S. W. Ryter, and A. M. K. Choi, Ann. Rev. Pharmacol. Toxicol., 2006, 46, 411;
L. Wu, and R. Wang, Pharmacol. Rev., 2005, 57, 585; S. W. Ryter, J. Alam, and A. M. K. Choi, Physiol.
Rev., 2006, 86, 583.
2 C. L. Hartsfield, Antioxid. Redox Signal. 2002, 4, 301.

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