Page 118 - Book of Abstracts

th
8 Biannual Conference on Chemistry - CHEM 08

Synthesis, Spectral, MOE and Cytotoxic Studies of Some

Lanthanide Metal Complexes of New Nano-bidentate Schiff
Base Ligand Based on of 2-Acetyl ferrocene with 2-

Aminophenol
Nessma F. Mahmoud, Walaa H. Mahmoud, Gehad G. Mohamed
Chemistry Department, Cairo University, Faculty of Science, Gamma
Street, Giza, Cairo 12613, Egypt.

ABSTRACT

Three lanthanide metal complexes of La(III), Er(III) and Yb(III) metal ions with
HL prepared through (1:1 condensation of 2-acetylferrocene with 2-aminophenol)
were prepared and characterized using various physio-chemical methods like:
elemental analyses, IR, mass spectrometry, SEM and TG/DTG thermal analysis.
The analytical and spectroscopic tools showed that the complexes had
composition of ML type with octahedral geometry. The molar conductance
revealed that all the metal chelates were electrolytes having the general
composition [M(L)(Cl)(H2O)3]Cl·4H2O. The mass spectra gave the possible
molecular ion peaks of the three metal chelates. Thermal analysis (TG/DTG) was
utilized to differentiate between coordinated and hydrated water molecules. The
results of these studies showed that the metal complexes are more effective
antibacterial and antifungal agents as compared with the free ligand. The
anticancer activity was screened against human breast cancer cell line (MCF-7).
Results indicated that metal complexes showed an increased cytotoxicity in
proliferation to cell lines as compared to free ligand. Molecular docking studies
were performed to identify the binding orientation or conformation of a complex
in the active site of the protein. HL and its complexes were docked with crystal
structure of DDB1 of breast cancer, crystal structure of HCV, RNA-dependent
RNA polymerase, receptors of HBV core protein, crystal structure of the Fab
fragment of anti-HAV.

BOOK OF ABSTRACTS CHEM 08 (2020) Page 117