Page 50 - Org 3 theoritical book 2024-25
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Clinical Pharmacy PharmD - 2024/2025                  Level 2                Pharmaceutical Organic Chemistry-3 (PC 305)















































                                   Azoles containing two heteroatoms

                                       Azoles with two nitrogen atoms

                                            (pyrazole and imidazole)














               •  Pyrazole and imidazole are aromatic in character and so they are resistant to

                   oxidation and addition reactions,

               •  Undergo  electrophillic  substitution  mostly  at  the  4-position  (more  electron

                   density).
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