Page 71 - Org 3 theoritical book 2024-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)
Seven-Membered Rings with

One or Two Heteroatoms
Benzazepines:

The seven-membered heterocycles, especially those condensed with one or two

benzene rings have been only studied in the last four decades. They quickly acquired

great attention due to the psychopharmacological activity of some derivatives of these

ring systems, e.g., imipramin which is a dibenzazepine derivative and is used as an

antidepressant agent

10 11
9 1
8 2
7 6 5 4 3
N
CH CH CH N(CH )
3 2
2
2
2

Imipramin
5-(3-dimethylaminopropyl)-10, 11 dihydro 5H-dibenzo [b,f]azepine