Page 111 - Pharmaceutical Organic Chemmistry-3 (Theoritical book) 24-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)

Technique

• In traditional IR spectroscopy, a dispersive • FTIR is a more modern technique as it
monochromator prism is used to separate employs an interferometer instead of
infrared light into its different monochromator prism to simultaneously

wavelengths. collect data over a wide range of
• A detector then measures the intensity of infrared wavelengths.
each wavelength individually as it passes • This data is then transformed using a
through the sample in a time-consuming Fourier algorithm to obtain an IR
process. spectrum.

• Slower time of analysis • Faster time of analysis

• Sample preparation is required • Little to No sample preparation is
required

• Lower resolution & sensitivity • Higher resolution (sharper well resolved
peaks) & sensitivity (lower sample
concentrations could be analyzed)

❖ In pharmaceuticals, IR spectroscopy identifies drugs (by
their specific function groups), excipients, and impurities to
ensure drug quality.

❖ Infrared spectroscopy helps in assessing air quality, water
contamination, and soil pollution by detecting pollutants as
volatile organic compounds (VOCs).

❖ IR spectroscopy verifies food authenticity, detecting
adulterants, and spoilage indicators.