Page 119 - Pharmaceutical Organic Chemmistry-3 (Theoritical book) 24-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)

[M ] peak
+
+
+
+
• Molecular ion peaks (M ) is • Molecular ion peaks (M ) • Molecular ion peaks (M )
small or absent. are present, but with very are present.
low intensity (may be
absent).
Fragmentation Pattern
• Cleavage of the C-C bond • Fragments appear due to • In short chain acids, peaks
next to the OH usually bond cleavage next to due to the loss of OH
occurs. C=O (alkoxy group loss, (-17 m/z) & COOH
• A loss of H2O may also -OR) (-45 m/z) are prominent
occur as in the spectra due to cleavage of bonds
below. next to C=O.

Example