Page 120 - Pharmaceutical Organic Chemmistry-3 (Theoritical book) 24-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)

• 2-decimal digits (16.05) and may not be • 4-decimal digits (16.0472)
enough to distinguish between two
molecules having same molecular mass.

• Low resolution & low accuracy, where two • High resolution & high accuracy, that
different compounds with almost similar they can detect the minute differences in
Mwt would appear to be identical. mass between two compounds with very

minor structural differences.

❖ In pharmaceuticals, MS spectroscopy identifies drugs and its
+
metabolites (by detecting their specific M ion peak).

❖ In chemical synthesis, MS spectroscopy could be used in

structure elucidation step in reactions monitoring by
detecting the specific ion peaks of certain reaction
intermediate or product.

❖ In biomedical purposes, MS spectrometry could analyze the
characteristics of proteins and the sequencing of peptides.

❖ In environmental analysis, water testing, pesticide screening,
and trace elemental analysis of heavy metals leaching.

❖ In forensic science, MS spectroscopy could detect drug abuse
or explosive residues that may be found at crime scenes.