Page 124 - How to Beat Cancer and Live Forever!
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               ketogenic diet will also reduce your risk of other chronic diseases and

               extend your lifespan.


               How Therapeutic Ketosis Fights Cancer

               Cancer cells cannot use ketones for fuel because of their mitochondrial

               defects. They require an
                                                           ✓  INCREASING CANCER CELL OXIDATIVE STRESS
               abnormally higher amount                    ✓  BEING ANTI-ANGIOGENESIS

               of glucose than normal cells                ✓  LOWERING INSULIN LEVELS
               and have 20 times more                      ✓  REDUCING INFLAMMATION

               insulin receptors than                      ✓  PROMOTING APOPTOSIS (PROGRAMMED

               normal cells. The increased                     CELL DEATH)

               amount of insulin receptors and hyperactive glucose consumption of
               cancer cells leads to continued stimulation of cancer development and

               growth.  Being in a state of Therapeutic Ketosis deprives cancer cells of
               glucose, while protecting and strengthening normal cells, which can use

               ketones for energy.  Cancer cell glycolysis and proliferation are

               thereby inhibited.


               Now to get a bit more scientific, additional anticancer effects of

               nutritional ketosis include:
                   ▪  Acts as an inhibitor of histone deacetylases (which reduces the ability of

                       cancer cells to proliferate).
                   ▪  Activates the AMPK (Adenosine Monophosphate-activated
                       Protein Kinase) pathway.  AMPK is an energy-regulating molecule

                       that signals ATP production.  Studies show that AMPK is involved

                       in cancer cell growth and survival and its activity is decreased in
                       cancer.  By upregulating the AMPK pathway, nutritional ketosis

                       deprives cancer cells of glucose.  Therefore, evidence shows
                       AMPK inhibits cancer cell growth and tumorigenesis via regulation

                       of mitochondria‐mediated metabolism.



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