Page 32 - Physiology and Pathophysiology MNU 2024-2025 نظرى
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Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)
Autonomic control of bladder function
During filling of the bladder During micturition
sympathetic control predominates causing. parasympathetic control predominates causing.
a. relaxation of the detrusor muscle a. Contraction of the detrusor muscle
b. contraction of the internal sphincter b. relaxation of the internal sphincter.
Effects of sympathetic and parasympathetic divisions on various organs
Sympathetic Parasympathetic
Organ Action Receptor Action Receptor
Heart
SA node, heart rate ↑ β1 ↓ M2
AV nodal conduction ↑ β1 ↓ M2
Contractility ↑ β1 ↓ (atria only) M2
Vascular Smooth Muscle
Skin; splanchnic Constricts α1
Skeletal muscle Dilates β2
Endothelium Releases EDRF M3
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