Page 133 - pharma 1 theoretical updated MNU_Neat
P. 133
Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)
Cardiac Action Potential phases
Ventricular myocytes SA node
Resting membrane Equal inward and spontaneous
+
Phase 4 Na influx
potential outward depolarization
Rapid depolarization
2+
Phase 0 Na influx Ca influx
+
depolarization phase
Early Na influx, K
+
+
Phase 1 ---------- --------
repolarization outflux
Balance between
2+
Phase 2 plateau Ca influx, ------------ -----------
+
K outflux
2+
Phase 3 Rapid Ca influx, repolarization K outflux
+
repolarization K outflux
+
Refractory period
| P a g e - 117 -
