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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)
Inhibitor

Fondaparinux

A synthetic analogue of the antithrombin-binding Pentasaccharide
It’s
sequence

binds only to antithrombin, catalyzes factor Xa inhibition by antithrombin
MOA
and does not enhance the rate of thrombin inhibition.

Reversal: No antidote, FFPs bleeding emergency

 Hirudin

➢ Alternatives to heparin in case of HIT

Lepirudin Bivalirudin

 a recombinant hirudin,  Acts as a direct thrombin inhibitor.
 is licensed for anticoagulation in patients  licensed for anticoagulation in
with immune HIT who require parenteral patients undergoing percutaneous

antithrombotic treatment coronary intervention (PCI).

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