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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)
3- Antiplatelet Drugs

(Platelet aggregation Inhibitors)

Classification

1) COX-1 Inhibitors Aspirin, Indobufen and Triflusal
2) (PDE-3) Inhibitors Dipyridamole
Thienopyridines
3) ADP receptor/Platelet P2Y12 (Ticlopidine, Clopidogrel, Prasugrel

Purinergic Receptor inhibitors
ticagrelor and cangrelor)
4) Glycoprotein IIb/IIIa Receptor Abciximab, Eptifibatide and Tirofiban

(Fibrinogen receptor) inhibitors

 Mechanism

Molecules that do not allow platelets to aggregate and thus prevent clotting,

especially in the arteries, are called anti-platelet agents.
They either
a) Reducing the formation

b) inhibiting the factors that promote platelet aggregation

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