Page 184 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)
Alprostadil

 It is given as intravenous infusion to Maintain the potency of the ductus arteriosus in

case of pulmonary hypertension or pulmonary artery stenosis.

Misoprostol

 Misoprostol is used to protect the mucosal lining of the stomach during chronic NSAID
treatment to decrease the incidence of NSAID-induced gastric ulcers.

 Misoprostol interacts with prostaglandin receptors on parietal cells within the stomach,
reducing gastric acid secretion.
 Furthermore, misoprostol has a GI cytoprotective effect by stimulating mucus and

bicarbonate production.
 Misoprostol is also used off-label in obstetric settings for labor induction, since it
increases uterine contractions by interacting with prostaglandin receptors in the
uterus.

 Misoprostol has the potential to induce abortion. Therefore, the drug is contraindicated
during pregnancy.

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