Page 68 - Community pharmcy practice E-book 2025

01/11/2025, 22:08 Medication Errors & Constipation Management

Should be avoided in patients taking
H2 blockers

Stimulant Laxatives Market Changes

Phenolphthalein (in Picolax® oral drops) was removed from the market as
suggested by FDA due to possible carcinogenicity
Cascara and aloe were banned by the FDA in 2002 for over-the-counter sales

Castor Oil

Cathartic effects (excessive fluid and electrolyte loss) leading to dehydration. It is
mainly used to evacuate the GIT contents prior to GIT operations.
Warning: It shouldn't be used in pregnant women as it may cause premature labor.
It can erode intestinal villi or disorganize the microvillous surface of the intestinal
lumen so long term use leads to nutrient malabsorption.
Dose: Adult: 15-60 ml; Children (2-12 years) 5-15ml

Castor oil can be misused to hasten delivery to induce premature uterine
contractions; however this is deadly since it can cause amniotic fluid embolism and
impaired health of the infant.

Lubricant Laxatives

Mechanism of action: Act at the colon to increase water retention in the stool
(coat) to soften it
Onset of action:

6-8 hr orally
5-15 minutes rectally
Examples & marketed products: Mineral oils as liquid paraffin

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