Page 169 - Phytochemistry 2 (06-PG 605)
P. 169

Semisynthetic Derivatives

*Topotecan
Topotecan hydrochloride
 (Hycamtin)that is a
 topoisomerase 1 inhibitor.
FDA approval on October, 2007

Topotecan is the first topoisomerase I inhibitor for oral use.

Uses:             Ovarian cancer and lung

cancer.

Administration:   IV and Oral

*Irinotecan:

Uses: Treatment of metastatic colorectal cancer

(first-line therapy when administered with 5-fluorouracil

and leucovorin).

Adminstration:    IV
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