Page 169 - Phytochemistry 2 (06-PG 605)
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Semisynthetic Derivatives
*Topotecan
Topotecan hydrochloride
(Hycamtin)that is a
topoisomerase 1 inhibitor.
FDA approval on October, 2007
Topotecan is the first topoisomerase I inhibitor for oral use.
Uses: Ovarian cancer and lung
cancer.
Administration: IV and Oral
*Irinotecan:
Uses: Treatment of metastatic colorectal cancer
(first-line therapy when administered with 5-fluorouracil
and leucovorin).
Adminstration: IV