Page 24 - Phytochemistry 2 (06-PG 605)

Proto alkaloids (Non-heterocyclic alkaloids)

The nitrogen atom in the alkaloids of this group is not involved in heterocyclic ring.

I- Alkaloids of the phenylalkylamine group
II- Tropolone alkaloids (Colchicine )
III-Diterpene alkaloids (Taxol)

I- Alkaloids of the phenylalkylamine group

The principle alkaloids of this group which have pharmacological activity are
Ephedra, Cathe, Peyote and Capcicum alkaloides.

1- Ephedra alkaloids

Ephedrine
Ephedrine occurs in E. sinica and in E. equisetina and associated with d-ψ-

ephedrine in E. vulgaris.

Ephedrine has two chiral centres, giving rise to four stereoisomers.

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