Page 79 - Phytochemistry 2 (06-PG 605)

B - The lysergic acid amides; and these are amide alkaloids that
are derived from lysergic acid. Again this amide alkaloids class
can be further distinguished into two subclasses:
i- The simple lysergic acid amides; that are built up of
lysergic acid and a simple amine.
ii- The polypeptide alkaloids; that are complex amides of
lysergic acid with several (three) different amino acids.

The clavine alkaloids

The names of the alkaloids of this class all end in ( –clavine),

e.g. agroclavine, elemoclavine and penniclavine….etc.

They are all simple water-soluble bases. They are not as

physiologically active as the lysergic acid derivatives, so they are

of little medicinal value. Few examples have been shown recently

to have significant oxytocic activity.

Examples of clavine alkaloids

HOH2C H3C H3C
NH
NCH3 NCH3

HOH2C NH NH NH

Elymoclavine Festaclavine Agroclavine

OH HO NCH3
HOH2C

NH NH

Chanoclavine Penniclavine

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