Page 58 - Biochemistry2 (08PB403)
P. 58

Conversion of Pyruvate
                  to Acetyl-CoA

• Pyruvate is converted to Acetyl-CoA in a complex reaction
  called oxidative decarboxylation catalyzed by the enzyme
  Pyruvate Dehydrogenase Complex as follows:

              Pyruvate DH complex
Pyruvate ------------------------- Acetyl- CoA

             TPP, Lipoic acid, CoA,
                    FAD, NAD

• The reaction requires 5 coenzymes:
  (Thiamin-PP (TPP), Lipoic acid, CoA, FAD and NAD)

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