Page 126 - phytochemistry II -pharmD general
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Hepatoprotective
Mechanism of action
Increase:
a. glutathione content.
b. superoxide dismutase.
c. bile secretion.
d. bilirubin, cholesterol and bile acid excretion
Decrease
a. Lipid peroxidation (Liver).
b. Xanthine & aldehyde oxidase.
c. GPT, GOT, γ GTP, ALT.
Anti-hypercholesterolemic
Coronary heart disease is attributed to developing of 3-hydroxy-3-methylglutaryl
Co A reductase (HMG-Co A).
Mechanism of action
✓ Inhibit HMG-Co A reductase.
✓ Decrease LDL, cholesterol, plasma lipid peroxide.
✓ Increase HDL.
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