Page 306 - Applied Pharmacognosy

Types of Chemical markers

 Variability in test results due to rabbit species to
species characteristics.

 The rabbit test is insufficiently sensitive for
endotoxin detection in intrathecal drug products.

The bacterial endotoxin test

Recently, the USP recognizes 2 tests; the pyrogen
test conducted with rabbits, and the bacterial
endotoxin test, also termed the Limulus Amebocyte
Lysate (LAL) test.