Page 101 - COMMUNITY PHARMACY PRACTICE
P. 101

02/04/2024

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     Emollient laxatives (Stool softeners)

        Mechanism of     onset of action:          Examples &
             action     • Slow (12-72hrs)           marketed
                        • Best for patients          products
     • Surfactants…so
       allowing           who must avoid     • Docusate sodium
       absorption of      straining to pass    (AOT) (Minalax ®
       water into the     hard stools as       tablets , with
       stool, which       those who            bisacodyl…..not in
       makes the          recently have a      pregnancy)
       softened stool     myocardial
       easier to pass.    infarction or      • New products
                          rectal surgery       …Docusate only

                                             • Doc Ca ..

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     Emollient laxatives (Stool softeners)…..

     Adverse effects &                       Imp Patient
     contraindications                        couseling

     • Diarrhea & mild          • patients who must avoid
       abdominal cramping         straining to pass hard stools
                                  as those who recently have a
     • Smaller doses for          myocardial infarction or rectal
       children<6yrs              surgery

     • Not with mineral oil     • Good for pregnant (cat C)
       (granulomatosis)or low   • Each dose must be taken
       therapeutic index drugs
       (facilitate absorption)    with at least 1 cup of water to
                                  prevent throat irritation) .

                                • Liquid preparations should be
                                  taken in fruit juice to increase
                                  palatability

                                • Do not use this product for
                                  more than 1 week unless
                                  directed by your doctor
                                  (dependence)(medscape).

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