Page 99 - COMMUNITY PHARMACY PRACTICE

02/04/2024

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Bulk-forming laxatives

• polysaccharide derivatives

• Bulk laxatives are replacements for lack of foods containing fiber,
such as fruit and vegetables

• The daily diet should contain approximately 25 to 50 g fiber.

• The lack of bulk results in failure of activation of receptors
necessary for defecation.

• Fiber binds fats and lipids from foods, and soluble fiber such as
oatmeal is more effective than insoluble fiber like psyllium in this
process. This reduction of fat and lipid absorption in the GI tract
may reduce cholesterol levels.

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Bulk-forming laxatives

Mechanism of Onset of action: Examples &
action marketed products
• Slow (12-24 hr and
Absorb water to up to 72 hr) • Natural
soften the stool and • Dietary bran, guar
increase bulk, which • Not in acute
stimulates constipation gum, psyllium
peristalsis. (plantago seedin
The only laxatives cereals)
not systemically (Regumucil® ) ,
absorbed (locally malt soup extract,
acting) • Synthetic
• Methyl cellulose
• Polycarbophil
(Evak ®tablets)
and (Evaculax®
capsules).

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