Page 77 - COMMUNITY PHARMACY PRACTICE
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Drug interactions
• the effects of one drug are altered by the co-
administration of another drug, herbal
medicine, food, drink or other environmental
chemical agents.
• The net effect of the combination may
manifest as an additive or enhanced effect of
one or more drugs, antagonism of the effect
of one or more drugs, or any other alteration
in the effect of one or more drugs.
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• Drugs with narrow therapeutic index:
• Theophyllin, digoxin..
• Drugs with steep-dose response curve:
• Anticoagulants
• PK (INDUCER OR INHIBITOR)
• Drugs with similar pharmacological effects
• Extremes of age.
What s important? HOW
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