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Drug/food interaction
• Food interactions may predictably involve absorption
interactions but also effects on cytochrome P450
isoenzymes, leading to metabolic interactions.
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163
• monoamine oxidase inhibitor antidepressants
(MAOIs) and tyramine-containing
foodstuffs(cheese). Risk of life-threatening
hypertensive crisis
• Grapefruit juice is a potent inhibitor of
cytochrome P450 3A4 and causes clinically
relevant interactions with a number of drugs
including simvastatin and atorvastatin, thereby
increasing the risk of statin-induced adverse
reDacrtuiogn/sfosoucdh ianstemryaocptaiothny aenxdammyposleitsis.
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