Page 526 - Applied Pharmacognosy

B. Cyclization of polyketide chain 525

➢A poly-b-ketomethylene chain.
This chain is formed by
condensation of an acetyl unit
(or other acyl unit) with malonyl
or methylmalonyl units, with
concomitant decarboxylation

➢The cyclization of polyketide
chain of varying length is one of
the principal PWs for the
formation of aromatic
compounds.