Page 529 - Applied Pharmacognosy

Summary 528

Metabolic Pathway Starting material End product High energy molecules Important intermediates

Photosynthesis CO2 glucose ATP/ NADPH ---
Glycolysis Glucose (C6) Pyruvate (C3) ATP/NADH
Kreb’s cycle Pyruvate (C3) CO2 ATP/ NADH/FADH2 ----

PPP Glucose-6-P (C6) ---- NADPH Oxaloacetic acid
2-oxoglutarate
Mevlonate Acetyl CoA Isoprene unit (C5) -----
Erythrose-4-P (C4)
Non-mevalonate Pyruvate Isoprene unit (C5) ----- Ribose-5-P (C5)

Shikimic acid PEP Most aromatic compouds ----- IPP (C5)
Polyketide cyclization Erythrose-4-P NADPH DMAAPP (C%)
Some aromatic
Acetyl CoA or compounds (ex: IPP (C5)
Propionyl CoA anthaquinones) DMAPP (C%)

Chorismic acid
Prephenic acid

poly-b-
ketomethylene

chain