Page 113 - Pharmaceutics IV (02-06-01305)
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Ophthalmic DD: requirements
In practice
• The external eye can tolerate tonicity variations.
• The isotonicity limits of an ophthalmic preparation in terms of sodium
chloride range from 0.6% to 2% (200 to 400 mOsm) without marked
discomfort to the eye.
• In certain cases, hypotonic products (for dry eye) or hypertonic
products (for corneal edema) are used.
219
“
pH & buffering
220 110
Salma E. EL-Habashy
