Page 115 - Pharmaceutics IV (02-06-01305)
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Ophthalmic DD: requirements
Buffering considerations:
• Buffer capacity is the key for pH compromise.
• Buffer capacity should be adequate for stability but minimized, to
allow for the rapid neutralization of the instilled drop and thus
minimal irritation and reflex tearing.
• Formulations that target the extremes of the acceptable pH range
(like corticosteroids acidic suspensions) will have better patient
acceptability if the formulations have a low buffering capacity.
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Clarity
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Salma E. EL-Habashy
