Page 126 - Pharmaceutics IV (02-06-01305)
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Ophthalmic DD: Excipients
Examples:
Water soluble polymers: poly (vinyl
alcohol), poly (vinylpyrrolidone) and
various cellulose derivatives:
methylcellulose, hydroxypropyl
methylcellulose and carboxymethyl
cellulose.
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Ophthalmic DD: Excipients
Requirements:
Viscosity range be below pain threshold.
• Pain sensation occurs above 300 cP.
• Solutions containing viscoelastic material
(sodium hyaluronate and Carbopol) can be
used at higher viscosities (shear-thinning
materials on blinking).
246
Salma E. EL-Habashy
