Page 205 - Pharmaceutics IV (02-06-01305)

It causes constipation &discolor stools blue.
-Radioimmunotherapy :It is the targeting of radioisotopes to
specific cells ,tissues ,& tumor types by covalent conjugation of a
radioisotope to monoclonal antibodies or their antigen-binding
fragments .e.g. 131 I can be conjugated to by using (NHS)
to produce radiolabeled antibodies . Copper isotope ,67 Cu can
conjugate to antibodies by using the chelating agent (TETA) for
radioimmunotherapy.
Radiation Detection Equipments
1-Scintillation detector : Detect gamma radiation emitting probes.
It can be modified to detect the localization of isotopes in the
organ of interest, e.g. detection of 131 I uptake by the thyroid& the
uptake of red blood cells labeled with 51 Cr by the spleen.
2-Scintillation counters: Used for detection & measurement of
ionizing radiation & can be used to test samples of in vitro testing

( drug release or dissolution ) & in vivo samples after digestion into
a homogeneous liquid (such as biodistribution studies ) .
4- Geiger Counter
Device to measure ionizing radiation most commonly used by the
laboratory safety personnel .It detects ionizing radiations
,including alpha, beta particles ,& gamma rays .
2- Positron emission tomography (PET
It is a function emitting technique applied in nuclear medicine to
measure whole body metabolism . It detects gamma rays emitted
by a positron-emitting radionuclide 18 F fluorodesoxyglucose

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