Page 24 - Pharmaceutics IV (02-06-01305)

Parenterals: Routes

• Desired rate of onset of action: (IV vs. IM vs. SC)
• Location of drug action (intraarticular, intraocular, CNS, ...)
• Injection volume: The volume of drug injected is lower for SC than

for IM or IV routes.

Considerations for route selection

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Parenterals: Routes

• Tissue irritability: Injection of an irritant drug is likely to be more
painful by the IM than the SC route due to higher blood flow and
sensory innervations in the muscles. On the other hand, IV shows
less pain.

Considerations for route selection 21

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Salma E. EL-Habashy