Page 159 - Pharm.Org.Chem-I 02-06-05-101

The benzene ring is named as a substituent (phenyl) in the following cases:
1- if it’s attached to a side chain having more than six carbon atoms.

2- if it’s attached to a side chain containing functional group

5

4

1 2
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3

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Reactions of Aromatic Compounds

Nucleophilic Electrophilic
reactions reactions
(Rare)

Electrophilic aromatic substitution reactions (SE2ar.)

Aromatic compounds such as benzene undergo electrophilic aromatic substitution reactions:
an electrophile substitutes for one of the hydrogens attached to the benzene ring.

E

Electrophile (Electron loving) (E+): electron-deficient species as: Cl+ or Br+ (halonium ion) and
+ NO2 (nitronium ion).

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