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2. Friedel-Craft acylation of benzene.
Friedel-Craft acylation is used to synthesize alkyl benzenes that cannot be
prepared by Friedel-Crafts alkylation because of rearrangements.
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Reactions of Alkyl Derivatives
1.α- Halogenation:
Halogenation will selectively substitute for a benzylic hydrogen in radical
substitution reaction
Benzylic carbon
Propylbenzene (1-Bromopropyl)benzene
➢ A halogen placed in the benzylic position, can be replaced by a
nucleophile via an S 2 or S 1 reactions.
N N
A wide variety of substituted benzenes can be prepared this way.
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