Page 178 - Pharm.Org.Chem-I 02-06-05-101

➢ Orientation of the third E++ follows the more electron donating group.

OH is Electron donating, Both groups are Electron
so E+ enters ortho to OH withdrawing groups so E+

enters m-position

Acetamido group is more electron
donating than methyl group,

so E+ enters ortho to the acetamido group

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Derivatives of benzene

I- Alkyl benzene

Preparation of alkyl derivatives
1. Friedel-Craft alkylation of benzene.

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