Page 173 - Pharm.Org.Chem-I 02-06-05-101
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I- o- ,p- orienting groups
1- Strongly activating o, p- orienting groups:
e.g. NH2, -NHR, -NR2, -OH, O-
+ R >> -I
2- Moderately activating o, p- orienting groups:
e.g. NHCOR, OR
+ R > -I
-ve charge is on o- & p- positions so it accepts an E+
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3- Weakly activating o, p- orienting groups:
e.g. R (CH3, C2H5), phenyl
Exert +I effect and hyperconjugation
-ve charge is on o- & p- positions
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